ExpectedOutcome:
This topic aims at supporting activities that are contributing to one or several of the expected impacts for this call. To that end, proposals submitted under this topic should aim at delivering results that are contributing to some of the following expected outcomes:
Proposals submitted under this call topic are expected to advance knowledge on Ebola virus disease with the aim of contributing to an efficient patient management and public health response, as well as better epidemic preparedness in Africa. Special focus should be on improving our understanding of the Sudan virus disease, in view of the recent outbreak in East Africa and the lack of available interventions for this viral strain. There are currently no licensed vaccines or therapeutics for the prevention and treatment of Sudan virus disease[1].
Ebola is a severe disease, with high mortality risk, first identified in 1976 when two simultaneous outbreaks occurred in South Sudan and the Democratic Republic of the Congo. Ebola viruses are primarily transmitted to humans through close contact with blood, secretions, organs, or other bodily fluids of infected humans or animals, and contaminated surfaces and materials. Infected people generally present with fever, fatigue, muscle pain, headache, and sore throat, followed by vomiting, diarrhoea, rash, and/or symptoms of impaired kidney and liver function. The average Ebola case fatality rate is estimated around 50% with rates varying from 25% to 90% in past outbreaks. Ebola outbreaks have most commonly been caused by the Zaire and Sudan Ebola virus.
The scope of the proposals submitted under this call topic should include one or more of the following areas:
Promotion of close communication between clinical experts, patient communities, regulators, health care workers and policy makers is expected to increase the uptake of a developed intervention and improve outbreak response.
Interaction with relevant national public health institutes and regulatory authorities, African Medicines Agency, Africa Centres for Disease Control and Prevention, World Health Organization - Regional Office for Africa and/or other regional and international relevant organisations are expected to adequately address research needs.
Vulnerable populations need to be included in the clinical study population, including children, pregnant women, people with co-infections and comorbidities, older people and people living in hard-to-reach communities (unless excluded for physiologic or metabolic reasons). Collaboration and coordination with existing outbreak response initiatives and ongoing Ebola research actions are highly encouraged to facilitate knowledge exchange, collaboration, synergies, and coordination of response activities. Community engagement should be supported.
Sex and gender aspects should be taken into account. All data should be disaggregated by sex, age, and other relevant variables, such as by measures of socioeconomic status (i.e., considering the socioeconomic gradient).
[1]https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON410
Expected Impact:Expected impacts of the calls under the 2023 work programme of the Global Health EDCTP3 JU
Activities funded under the 2023 calls for proposals should contribute to:
[1]Working document of the AU EU Innovation Agenda available online at: https://research-and-innovation.ec.europa.eu/system/files/2022-02/final_au-eu_ia_14_february.pdf