A COMPREHENSIVE ‘PAEDIATRIC PRECLINICAL POC PLATFORM’ TO ENABLE CLINICAL MOLECULE DEVELOPMENT FOR CHILDREN WITH CANCER

Topic description

Specific Challenge:

Paediatric cancer:

20% of all paediatric cancer remains incurable

Long term side effects associated with treatment

Cancer is often much more advanced, i.e., metastatic, in children then adults

Effective and safe treatments are urgently needed

Build a comprehensive translational network of PDX models, matching cell lines/organoids and genetically modified mouse models with complete molecular characterization and proven relevance to major solid paediatric tumours.

Increasing the number of cures across a wide range of paediatric cancer histologies (more lives saved);

Potentially mitigating the long term health effects typically associated with conventional chemotherapeutic, better quality of life