Specific Challenge:
The increasing availability of novel biomaterials with tissue regeneration properties[1] offers the solution for many diseases, including those of a degenerative nature, particularly as integral parts of advanced therapy medicinal products or medical devices. These disorders are often poorly amenable to current healthcare interventions. The design of new biomaterials capable of inducing tissue specific regeneration, which can derive from many different pathological processes or tissue defects, as elements of these medical technologies, results from their increasing fusion/combination. The production of these technologies is highly warranted. EU intervention in this field is required to achieve this goal and thereby develop new and innovative affordable technologies delivering personalised services.
Scope:Research activities on functional biomaterials for regenerative medicine should show their advanced properties and their eventual field of application. These may include association with pluripotent stem cells, biostimulators, microfluidic devices, cellularised and/or biomimetic scaffolds, biological agents and appropriate disease models etc.
Proposals should cover one of the following domains:
Proposals should address relevant local, national and international ethical and regulatory requirements, take into account gender aspects and include a section on research data management.
Proposals should liaise with a broad and multidisciplinary community of stakeholders (e.g. in the form of a user committee) and should include the appropriate disciplines of Social Sciences and Humanities (SSH) working in the health domain. Therefore, proposals should foresee a dedicated work package for cooperation and earmark appropriate resources
Proposals submitted under this topic should include a business case and exploitation strategy, as outlined in the Introduction to the LEIT part of this Work Programme.
Activities should start at TRL 3 and achieve TRL 5 at the end of the project.
The Commission considers that proposals requesting a contribution from the EU of between EUR 4 and 6 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.
Expected Impact:Relevant indicators and metrics with baseline values must be clearly stated in the proposal.
Cross-cutting Priorities:International cooperation
Gender
Open Innovation
[1]Reference is made to the topic of regenerative medicine: “Reliable and accessible information on future therapies in regenerative medicine”, CSA from Societal Challenge 1